In this rubric we present you scientific news from the world of chitin and chitosan. Monthly you can find recent publications. We hope to arouse your interest in this biopolymer or to help you out. If you have any comments or if you do chitin or chitosan research and you want to publish your article on this page,
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Hydrogels can have versatile applications in biomedicine by forming a 3D network. In the study presented here, an antibacterial, adhesive, self-repairing hydrogel was prepared from carboxymethylchitosan (CMC) and oligomeric polycyanidin (OPC) and the influence of OPC content was investigated.
hydrogels, Crosslinking, carboxymethylchitosan, chitosan oligomer
Glioblastomas are difficult to treat due to the blood-brain barrier and drug resistance. To improve the efficacy of treating glioblastomas with selenium nanoparticles (Se-NPs), Se-NPs were coated with chitosan in the presented study.
Small interferring RNAs (siRNAs) can inactivate viruses by so-called gene silencing. In order to use this process in biomedicine, the transport of unstable siRNAs must be improved. In the presented study, siRNAs are coupled to chitosan microparticles and investigated for the inactivation of viral proteins in HIV-1 infected C8166 cells. siRNA transfection mediated by chitosan microparticles for the treatment of HIV-1 infections of human cell lines
drug delivery, chitosan, HIV-1, microparticle, siRNA Transfection
Vaccines based on recombinant protein antigens often require immunostimulants. Both nanoparticles and chitosan and its derivatives can enhance immunogenicity. For this reason, in the presented studies, PLGA nanoparticles were functionalized with different chitosan derivatives and optimized as effect enhancers for the pneumococcal protein antigen PspA4Pro.
Critical bone defects often require the use of bone grafts or artificial bone substitutes such as calcium phosphate cement (CPC) or magnesium phosphate cement (MPC). In the study presented here, MPC is modified with CMC and sodium alginate to form a novel bone cement and its properties are investigated in vivo and in vitro.
Regeneration, bone substitue, carboxymethylchitosan, bone repair, bone cements, bone tissue
Due to the increase of infectious diseases and the development of antibiotic resistance, new antibacterial substances are needed. In the presented study, novel chitosan-AgIO3 bionanocomposites were synthesized and their antibacterial properties were investigated.
chitosan, nanoparticles, wound dressing, antibacterial, sustainability