Chitosan Buccal Films for Captopril: When the Salt Form Influences Drug Transport
Captopril is a well-established drug used to treat hypertension and heart failure. However, conventional oral administration presents several challenges: although the drug is highly water-soluble, its ability to cross biological membranes is limited, it may be unstable in the gastrointestinal tract, and part of the absorbed dose is metabolized in the liver. Researchers from the Universities of Szeged and Debrecen therefore investigated an alternative approach: mucoadhesive chitosan films designed to deliver captopril through the buccal mucosa.

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