Chitosan Derivatives
In addition to classic chitins and chitosans, Heppe Medical Chitosan also produces derivatives of this material group. Our standard chitosan derivatives are Chitosan HCI (in various specifications), Carboxymethylchitosan, Chitosan Lactate, Chitosan Acetate and Chitosan Glutamate.
The advantage of these derivatives is that they are soluble in water and no additional acids need to be added. For all of our products we can make special product specifications for you.
Do you need an offer? Please contact us.
Chitosan HCl
- also known as Chitosan hydrochloride, Chitosan chloride, Chitosani hydrochloridum
- listed in Eur. Ph., suitable for medical applications
- quality according to Eur. Ph.
- soluble in water
- Molecular formula: H-(C8-H13-N-O5)n-H-O(C6H11-N-O4)n CL-H
In 2017 we have deversified our product range for chitosan HCl. Now we provide different specifications for degree of deacetylation and viscosity /molecular weight. Also high molecular weight chitosan chloride is now available. For an overview please see the following table. Minimum order size for product 44001 is 20gram. For 54047, 54039, 54040 and 54046 the minimum order quantity is 10gram.
These are our Chitosan HCL standard products:
| Chitoceuticals® Chitosan HCl | Article numbers | ||||
| Parameter | 44001 | 54040 | 54047 | 54039 | 54046 |
| Degree of Deacetylation [%] | 80-95 | 75-90 | >90 | 75-90 | >90 |
| Viscosity [mPas] | 2-200 | <20 | <20 | 20-200 | 20-200 |
| Molecular weight appr. [kDa] | 30-200 | <300 | <300 | 200-800 | 200-800 |
| Chloride content [%] | 10-20 | 10-20 | 10-20 | 10-20 | 10-20 |
| pH | 4-6 | 4-6 | 4-6 | 4-6 | 4-6 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
| Protein content [%] | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 |
| Microbiological tests | |||||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 |
| Yeast and Mould | ≤ 100 | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 |
| Heavy Metals [ppm] | |||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
Of course we offer also GMP compliant grades with a low bioburden and endotoxin content. The following Chitoceuticals GMP compliant grades are produced in cleanrooms according to EU-GMP guidelines. Minimum order quantity 10 gram. If you need a quotation please do not hesitate to contact us. At the moment our GMP compliant grades are not yet available in the web shop.
| Chitoceuticals® GMP compliant Chitosan HCl |
Article numbers | |||
| Parameter | 55040 | 55047 | 55039 | 55046 |
| Degree of Deacetylation [%] | 75-90 | >90 | 75-90 | >90 |
| Viscosity [mPa-s] | <20 | <20 | 20-200 | 20-200 |
| Molecular weight appr. [kDa] | <300 | <300 | 200-800 | 200-800 |
| Chloride content [%] | 10-20 | 10-20 | 10-20 | 10-20 |
| pH | 4-6 | 4-6 | 4-6 | 4-6 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
| Protein content [%] | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 |
| Microbiological tests | ||||
| Total bacterial count [cfu/g] | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| Yeast and Mould | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| E.coli [cfu/g] | absent | absent | absent | absent |
| P.aeruginosa [cfu/g] | absent | absent | absent | absent |
| St. Aureus [cfu/g] | absent | absent | absent | absent |
| Salmonella [cfu/g] | absent | absent | absent | absent |
| Endotoxins [EU/g] | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| Heavy Metals [ppm] | ||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
Carboxymethylchitosan
- example of application: treatment of wounds
- soluble in water
Chitosan Lactat
- odourless
- preferred use in cosmetic applications
- soluble in water
Chitosan Acetat
- possible field of application: wound dressing used for burnings
- soluble in water
Chitosan Glutamate
- application mainly in the following pharmaceutical fields:
- drug delivery
- enhancement of absorption abilities of APIs
- tissue engineering
- enhancement of mucoadhesive properties
Now we provide different specifications for degree of deacetylation and viscosity /molecular weight. Also high molecular weight chitosan glutamate is now available. For an overview please see the following table. Minimum order size for product 44006 is 20gram. For 54041, 54042 and 54043 the minimum order quantity is 10gram.
These are our Chitosan Glutamate standard products:
| Chitoceuticals® Chitosan Glutamate | Article numbers | ||||
| Parameter | 44006 | 54042 | 54041 | 54043 | |
| Degree of Deacetylation [%] | 80-95 | 75-90 | 75-90 | >90 | |
| Viscosity [mPa-s] | 2-200 | <20 | 20-200 | 20-200 | |
| pH | 4-6 | 4-6 | 4-6 | 4-6 | |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 | |
| Protein content [%] | ≤ 0.5 | ≤ 0.5 | ≤ 0.5 | ≤ 0.5 | |
| Microbiological tests | |||||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 | |
| Yeast and Mould | ≤ 100 | ≤ 1000 | ≤ 1000 | ≤ 1000 | |
| Heavy Metals [ppm] | |||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 | |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 | |
Of course we offer also GMP compliant grades with a low bioburden and endotoxin content. The following Chitoceuticals GMP compliant grades are produced in cleanrooms according to EU-GMP guidelines. Minimum order quantity 10 gram. If you need a quotation please do not hesitate to contact us. At the moment our GMP compliant grades are not yet available in the web shop.
| Chitoceuticals® GMP compliant Chitosan Glutamate |
Article numbers | |||
| Parameter | 55042 | 55041 | 55043 | |
| Degree of Deacetylation [%] | 75-90 | 75-90 | >90 | |
| Viscosity [mPa-s] | <20 | 20-200 | 20-200 | |
| pH | 4-6 | 4-6 | 4-6 | |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | |
| Protein content [%] | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 | |
| Microbiological tests | ||||
| Total bacterial count [cfu/g] | ≤ 100 | ≤ 100 | ≤ 100 | |
| Yeast and Mould | ≤ 100 | ≤ 100 | ≤ 100 | |
| E.coli [cfu/g] | absent | absent | absent | |
| P.aeruginosa [cfu/g] | absent | absent | absent | |
| St. Aureus [cfu/g] | absent | absent | absent | |
| Salmonella [cfu/g] | absent | absent | absent | |
| Endotoxins [EU/g] | ≤ 100 | ≤ 100 | ≤ 100 | |
| Heavy Metals [ppm] | ||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | |
Buy chitosan derivatives
In our Onlineshop you can purchase small amounts of chitosan derivatives. Do you need a specific derivative? Or are you looking for a detailed offer? Don't hesitate to contact the Sales department of Heppe Medical Chitosan. You need another derivative? Address us your request - we also offer custom manufacturing.