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Chitosan Buccal Films for Captopril: When the Salt Form Influences Drug Transport

Captopril is a well-established drug used to treat hypertension and heart failure. However, conventional oral administration presents several challenges: although the drug is highly water-soluble, its ability to cross biological membranes is limited, it may be unstable in the gastrointestinal tract, and part of the absorbed dose is metabolized in the liver. Researchers from the Universities of Szeged and Debrecen therefore investigated an alternative approach: mucoadhesive chitosan films designed to deliver captopril through the buccal mucosa.

drug delivery

Polynucleotide-Chitosan Formulation for the Intra-Articular Treatment of Osteoarthritis

Osteoarthritis is one of the most common degenerative joint diseases. It is characterized by progressive cartilage degradation, pain, restricted mobility, and increasing impairment in everyday life. A particular challenge is that articular cartilage has only a limited capacity for regeneration and structural damage frequently continues to worsen.

drug delivery, joint, Arthritis

Chitosan-Based Tissue Adhesive for Controlling Severe Bleeding

Severe bleeding from internal organs is one of the greatest challenges in surgery and trauma care. The liver, spleen, kidneys, and lungs are particularly difficult to treat because these organs are soft, highly vascularized, and mechanically delicate. Conventional methods such as suturing, cauterization, or vessel ligation are not always feasible and may additionally damage healthy tissue.

wound treatment, Hydrogel, tissue

Injectable Carboxymethyl Chitosan Hydrogel for Bone Regeneration in Diabetes

Image has been AI generated

Diabetes mellitus significantly impairs bone healing. Elevated glucose levels promote oxidative stress, chronic inflammation, and impaired activity of bone-forming cells. As a result, bone defects in patients with diabetes often heal more slowly or incompletely. In addition, the increased risk of infection can further compromise regeneration.

Hydrogel, bone regeneration, diabetes