Crosslinking is a method to chemically or physically link polymer chains to modify mechanical, biological and degradation properties of hydrogels. Modification of mechanical strength, stability, swelling and permeability can be used for e. g. drug release systems. A large number of crosslinked chitosan-based materials have been investigated in research. Find out more about the advantages and applications of crosslinked chitosans in our articles below.
Artificially produced nerve conduits are promising alternatives to autologous nerve grafts in the treatment of damaged nerves. In this study, the physiochemical properties of chitosan/poly-ε-caprolactone nerve conduits will be improved by using the chitosan crosslinker genipin.
Chitosan bioglass networks can be used as biomaterials in medicine, for example, as bone implants. Their physiochemical and mechanical properties can be improved by crosslinkers and various stabilization methods. In the presented study, six of them were compared with each other.