Antibacterial, multifunctional hydrogel based on carboxymethylchitosan
Hydrogels can have versatile applications in biomedicine by forming a 3D network. In the study presented here, an antibacterial, adhesive, self-repairing hydrogel was prepared from carboxymethylchitosan (CMC) and oligomeric polycyanidin (OPC) and the influence of OPC content was investigated.
Carboxymethyl chitosan alginate as an enhancer of bone cement repair activity
Critical bone defects often require the use of bone grafts or artificial bone substitutes such as calcium phosphate cement (CPC) or magnesium phosphate cement (MPC). In the study presented here, MPC is modified with CMC and sodium alginate to form a novel bone cement and its properties are investigated in vivo and in vitro.
Carboxymethyl-beta-glucan/chitosan nanoparticles for antigen delivery
Various polysaccharides such as chitosan and β-glucan possess immunological properties that are advantageous for vaccine adjuvants. Therefore, in the presented study, chitosan and carboxymethyl-β-glucan were combined as nanoparticles, coupled to the model antigen ovalbumin as vaccine adjuvant and investigated in vivo in a mouse model.
Carboxymethyl chitosan for treatment of liver carcinomas
Hepatocellular carcinoma is a solid tumor that exhibits severe angiogenesis, cell cycle dysregulation, and evasion of apoptosis. Late diagnosis in a large proportion of patients is making the carcinomas inoperable, and various chemotherapeutic agents are used. Due to the numerous side effects of known chemotherapeutic agents, intensive research is performed on the use of natural products and their synthetic analogues. The authors of the presented study investigated the effect of carboxymethyl chitosan oligosaccharides on the growth of hepatocellular tumors in mice.
Carboxymethyl chitosan (CMC)
Properties of CMC:
- water soluble (pH>7)
- antibacterial
- antitumor
- antioxidant
- antifungal
Applications of CMC:
- Wound treatment
- drug transport and release (e.g. nanoparticles)
- Tissue engineering - bone tissue
- Hydrogels
- cosmetics
We offer N,O-carboxymethylchitosan in our three product lines Chitoscience®, Chitoceuticals®, and Chitoceuticals® GMP compliant.
In the table below, you will find an overview of the CMC product specifications available at HMC.
| Carboxymethylchitosan | Chitoscience® |
Chitoceuticals® | Chitoceuticals® GMP compliant |
| Article number | 43002 | 44002 | 45002 |
| Appearance of solid product | white to almost white | white to almost white | white to almost white |
| Appearance of solution | clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
| Dry matter content [%] | ≥ 90 | ≥ 90 | ≥ 90 |
| Degree of Deacetylation [%] | 80-95 | 80-95 | 80-95 |
| Viscosity [mPa-s] | 5-300 | 5-300 | 5-300 |
| pH | 7 - 9 | 7 - 9 | 7 - 9 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 |
| Insolubles [%] | ≤ 2 | ≤ 2 | |
| Heavy Metals [ppm] | |||
| Hg | ≤ 0.2 | ≤ 0.2 | ≤ 0.2 |
| Pb | ≤ 40 | ≤ 40 | ≤ 20 |
| As | ≤ 0.5 | ≤ 0.5 | |
| Cd | ≤ 0.5 | ≤ 0.5 | |
| Molecular weight appr. [kDa] | approx. 30-500 | to be measured | |
| Protein content [%] | ≤ 0.5 | ≤ 0.5 | |
| Microbiological tests | |||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | |
| Yeast and Mould [cfu/g] | ≤ 100 | ≤ 100 | |
| E. coli | absent | ||
| P. aeruginosa | absent | ||
| St. aureus | absent | ||
| Salmonella | absent | ||
| Endotoxins [EU/g] | ≤ 100 | ||
| Identity | IR spectra |
In our Onlineshop you can purchase small amounts of chitosan derivatives like carboxymethyl chitosan. Do you need a different specification? Are you looking for a detailed offer? Don't hesitate to contact our
Chitosan as pH-switchable emulsifier
An emulsion which is stabilized by solid particles absorbing onto the interface between the two phases is called a pickering emulsion. The particles prevent coalescence of the droplets. The development of particulate emulsifiers is highly interesting with many advantages over conventional surfactant systems. Beneficial are the higher stability, better size control and lower toxicity. In this research area the application of chitosan for development of pickering emulsions is promising.