World first chitosan molecular weight standards!
At EUCHIS 2023, HMC is launching chitosan standards for the first time. ,,We are proud to finally offer a reliable standard for molecular weight analysis'', says Katja Richter, Managing Director of Heppe Medical Chitosan. This means that researchers and customers no longer need to compare chitosans with other substances such as pullulan or PEG/PEO for molecular weight analysis. Now reliable chitosans can be used. No approximations. No thinking about whether they are the right, reliable results. Reliable chitosans for excellent research and outstanding pharmaceutical products.
Chitosan Lactate
Properties of Chitosan Lactate
- Odorless
- water soluble
Applications of Chitosan Lactate
- cosmetic applications
- wound treatment on mucosal surfaces
We offer the following standard specification of Chitosan in our three product lines Chitoscience® Chitoceuticals® and Chitoceuticals® GMP compliant. The minimum order quantity is 20 g, which you can easily order in our shop. If you need a detailed offer please contact our
The following table gives you an overview of our different chitosan lactate specifications:
| Chitosan Lactate | Chitoscience® |
Chitoceuticals® | Chitoceuticals® GMP compliant |
| Article number | 43003 | 44003 | 45003 |
| Appearance of solid product | white to light yellow | white to light yellow | white to light yellow |
| Appearance of solution | clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
| Dry matter content [%] | ≥ 90 | ≥ 90 | ≥ 90 |
| Degree of Deacetylation [%] | 80-95 | 80-95 | 80-95 |
| Viscosity [mPa-s] | ≥ 5 | ≥ 5 | ≥ 5 |
| pH | 3-7 | 3-7 | 3-7 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 |
| Insolubles [%] | ≤ 2 | ≤ 2 | |
| Heavy Metals [ppm] | |||
| Pb | ≤ 40 | ≤ 40 | ≤ 20 |
| Hg | ≤ 0.2 | ≤ 0.2 | ≤ 0.2 |
| Cd | ≤ 0.5 | ≤ 0.5 | |
| As | ≤ 0.5 | ≤ 0.5 | |
| Molecular weight appr. [kDa] | approx. 30-500 | to be measured | |
| Protein content [%] | ≤ 0.5 | ≤ 0.5 | |
| Microbiological tests | |||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | |
| Yeast and Mould [cfu/g] | ≤ 100 | ≤ 100 | |
| E. coli | absent | ||
| P. aeruginosa | absent | ||
| St. aureus | absent | ||
| Salmonella | absent | ||
| Endotoxins [EU/g] | ≤ 100 | ||
| Identity | IR spectra |
Do you need a specific derivative? Or are you looking for customer specification? Address us your request - we also offer custom manufacturing.
Chitosan acetate
Properties of chitosan acetate:
- watersoluble
Applications of chitosan acetate:
- Wound dressings - improved wound healing of burns
We offer the following standard specification of chitosan acetate in our three product lines Chitoscience® Chitoceuticals® and Chitoceuticals® GMP compliant. The minimum order quantity is 20 g, which you can easily order in our shop. If you need a detailed offer please contact our
The following table gives you an overview of our different chitosan acetate specifications:
| Chitosan Acetate | Chitoscience® |
Chitoceuticals® | Chitoceuticals® GMP compliant |
| Article number | 43004 | 44004 | 45004 |
| Appearance of solid product | white to light yellow | white to light yellow | white to light yellow |
| Appearance of solution | clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
| Dry matter content [%] | ≥ 85 | ≥ 85 | ≥ 85 |
| Degree of Deacetylation [%] | 80-95 | 80-95 | 80-95 |
| Viscosity [mPa-s] | ≥ 5 | ≥ 5 | ≥ 5 |
| pH | 3-7 | 3-7 | 3-7 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 |
| Insolubles [%] | ≤ 2 | ≤ 2 | |
| Heavy Metals [ppm] | |||
| Hg | ≤ 0.2 | ≤ 0.2 | ≤ 0.2 |
| Cd | ≤ 0.5 | ≤ 0.5 | ≤ 0.5 |
| Pb | ≤ 40 | ≤ 20 | |
| As | ≤ 0.5 | ≤ 0.5 | |
| Molecular weight appr. [kDa] | approx. 30-200 | to be measured | |
| Protein content [%] | ≤ 0.5 | ≤ 0.5 | |
| Microbiological tests | |||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | |
| Yeast and Mould [cfu/g] | ≤ 100 | ≤ 100 | |
| E. coli | absent | ||
| P. aeruginosa | absent | ||
| St. aureus | absent | ||
| Salmonella | absent | ||
| Endotoxins [EU/g] | ≤ 100 | ||
| Identity | IR spectra |
Do you need a different specification? Are you looking for a detailed offer? Don't hesitate to contact our
You need a different derivative? Address us your request - we also offer custom manufacturing.
Carboxymethyl chitosan (CMC)
Properties of CMC:
- water soluble (pH>7)
- antibacterial
- antitumor
- antioxidant
- antifungal
Applications of CMC:
- Wound treatment
- drug transport and release (e.g. nanoparticles)
- Tissue engineering - bone tissue
- Hydrogels
- cosmetics
We offer N,O-carboxymethylchitosan in our three product lines Chitoscience®, Chitoceuticals®, and Chitoceuticals® GMP compliant.
In the table below, you will find an overview of the CMC product specifications available at HMC.
| Carboxymethylchitosan | Chitoscience® |
Chitoceuticals® | Chitoceuticals® GMP compliant |
| Article number | 43002 | 44002 | 45002 |
| Appearance of solid product | white to almost white | white to almost white | white to almost white |
| Appearance of solution | clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
clear, colorless to slightly yellowish |
| Dry matter content [%] | ≥ 90 | ≥ 90 | ≥ 90 |
| Degree of Deacetylation [%] | 80-95 | 80-95 | 80-95 |
| Viscosity [mPa-s] | 5-300 | 5-300 | 5-300 |
| pH | 7 - 9 | 7 - 9 | 7 - 9 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 |
| Insolubles [%] | ≤ 2 | ≤ 2 | |
| Heavy Metals [ppm] | |||
| Hg | ≤ 0.2 | ≤ 0.2 | ≤ 0.2 |
| Pb | ≤ 40 | ≤ 40 | ≤ 20 |
| As | ≤ 0.5 | ≤ 0.5 | |
| Cd | ≤ 0.5 | ≤ 0.5 | |
| Molecular weight appr. [kDa] | approx. 30-500 | to be measured | |
| Protein content [%] | ≤ 0.5 | ≤ 0.5 | |
| Microbiological tests | |||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | |
| Yeast and Mould [cfu/g] | ≤ 100 | ≤ 100 | |
| E. coli | absent | ||
| P. aeruginosa | absent | ||
| St. aureus | absent | ||
| Salmonella | absent | ||
| Endotoxins [EU/g] | ≤ 100 | ||
| Identity | IR spectra |
In our Onlineshop you can purchase small amounts of chitosan derivatives like carboxymethyl chitosan. Do you need a different specification? Are you looking for a detailed offer? Don't hesitate to contact our
Chitosan Glutamate
Properties of Chitosan Glutamate
- water soluble
- antimicrobial
- antifungal
- mucoadhesive
Applications of Chitosan Glutamate
- hydrogels
- drug transport and release
- Enhancement of drug uptake
- tissue engineering
- Enhancement of adhesion properties e.g. to mucous membranes
At HMC we offer chitosan glutamate in various specifications with different degrees of deacetylation, viscosities and molecular weights. High molecular weight chitosan glutamate is also available. The minimum order quantity for the products 54041, 54042, 54043 and 54045 is 10g.
The following table gives you an overview of our different Chitosan Glutamate specifications:
| Chitoceuticals® Chitosan Glutamate | Article numbers | ||||
| Parameter | 54041 | 54042 | 54043 | 54045 | |
| Degree of Deacetylation [%] | 75-90 | 75-90 | >90 | >90 | |
| Viscosity [mPa-s] | 20-200 | <20 | 20-200 | <20 | |
| pH | 4-6 | 4-6 | 4-6 | 4-6 | |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 | |
| Protein content [%] | ≤ 0.5 | ≤ 0.5 | ≤ 0.5 | ≤ 0.5 | |
| Microbiological tests | |||||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 | |
| Yeast and Mould | ≤ 100 | ≤ 1000 | ≤ 1000 | ≤ 1000 | |
| Heavy Metals [ppm] | |||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 | |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 | |
Of course, we also offer our chitosan glutamate specifications in Chitoceuticals® GMP compliant quality. Our GMP-compliant products are manufactured in our clean rooms according to EU GMP guidelines. As a result, they have a very low endotoxin limit and a very low microbial load.
The minimum order quantity is 10g. Our GMP-compliant products are currently not yet available in our store, but can be ordered by email. We will be pleased to make you an offer, please
| Chitoceuticals® GMP compliant Chitosan Glutamate |
Article numbers | |||
| Parameter | 55041 | 55042 | 55043 | 55045 |
| Degree of Deacetylation [%] | 75-90 | 75-90 | >90 | >90 |
| Viscosity [mPa-s] | 20-200 | <20 | 20-200 | <20 |
| pH | 4-6 | 4-6 | 4-6 | 4-6 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
| Protein content [%] | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 |
| Microbiological tests | ||||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 |
| Yeast and Mould | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| E.coli [cfu/g] | absent | absent | absent | absent |
| P.aeruginosa [cfu/g] | absent | absent | absent | absent |
| St. Aureus [cfu/g] | absent | absent | absent | absent |
| Salmonella [cfu/g] | absent | absent | absent | absent |
| Endotoxins [EU/g] | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| Heavy Metals [ppm] | ||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
Chitosan HCl
- also known under the names: Chitosan hydrochloride, Chitosan chloride, Chitosani hydrochloridum
- listed in Eur. Ph., for medical applications
- Quality according to Eur. Ph.
- soluble in water
- molecular formula: H-(C8-H13-N-O5)n-H-O(C6H11-N-O4)n CL-H
Properties of Chitosan HCl
- Stronger swelling behavior than chitosan
- Water soluble
- Hemostatic effects
- Mucoadhesion
- Increases the permeability of tight junctions in the intestine
- Applications of Chitosan HCl
- Hydrogels
- Wound dressings
- Drug transport and release
We offer various Chitosan HCL specifications with different degrees of deacetylation and viscosities / molecular weights. High molecular weight chitosan chlorides are also available.
The minimum order quantity is 10g.
In the table below, you will find an overview of our offered Chitosan-HCl specifications.
| Chitoceuticals® Chitosan HCl | Article numbers | |||
| Parameter | 54040 | 54047 | 54039 | 54046 |
| Degree of Deacetylation [%] | 75-90 | >90 | 75-90 | >90 |
| Viscosity [mPas] | <20 | <20 | 20-200 | 20-200 |
| Molecular weight appr. [kDa] | <300 | <300 | 200-800 | 200-800 |
| Chloride content [%] | 10-20 | 10-20 | 10-20 | 10-20 |
| pH | 4-6 | 4-6 | 4-6 | 4-6 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
| Protein content [%] | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 |
| Microbiological tests | ||||
| Total bacterial count [cfu/g] | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 |
| Yeast and Mould | ≤ 1000 | ≤ 1000 | ≤ 1000 | ≤ 1000 |
| Heavy Metals [ppm] | ||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
Of course, we also offer our chitosan HCL specifications in Chitoceuticals® GMP compliant quality. Our GMP-compliant products are manufactured in our clean rooms according to EU GMP guidelines. As a result, they have a very low endotoxin limit as well as a very low microbial load. For our Chitosan-HCl products we also have a Drug Master File with the FDA.
Our GMP-compliant products are currently not yet available in the store and can be ordered by email. The minimum order quantity is 10g. We would be pleased to make you an offer, please
| Chitoceuticals® GMP compliant Chitosan HCl |
Article numbers | |||
| Parameter | 55040 | 55047 | 55039 | 55046 |
| Degree of Deacetylation [%] | 75-90 | >90 | 75-90 | >90 |
| Viscosity [mPa-s] | <20 | <20 | 20-200 | 20-200 |
| Molecular weight appr. [kDa] | <300 | <300 | 200-800 | 200-800 |
| Chloride content [%] | 10-20 | 10-20 | 10-20 | 10-20 |
| pH | 4-6 | 4-6 | 4-6 | 4-6 |
| Ash content [%] | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
| Protein content [%] | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 | ≤ 0.3 |
| Microbiological tests | ||||
| Total bacterial count [cfu/g] | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| Yeast and Mould | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| E.coli [cfu/g] | absent | absent | absent | absent |
| P.aeruginosa [cfu/g] | absent | absent | absent | absent |
| St. Aureus [cfu/g] | absent | absent | absent | absent |
| Salmonella [cfu/g] | absent | absent | absent | absent |
| Endotoxins [EU/g] | ≤ 100 | ≤ 100 | ≤ 100 | ≤ 100 |
| Heavy Metals [ppm] | ||||
| Pb | ≤ 10 | ≤ 10 | ≤ 10 | ≤ 10 |
| Hg | ≤ 1 | ≤ 1 | ≤ 1 | ≤ 1 |
How to read our certificate of analysis?
A certificate of analysis (CoA) is a document that confirms that the product meets its product specifications and is issued for each batch of product by quality assurance. The certificate of analysis contains the specifications for the specified parameters and the actual results of analysis of the parameters for this product batch. The certificate of analysis is sent together with the product to our customers. In the following we explain in detail how to read a certificate of analysis of our chitosan products and how can you cite it in your scientific articles.
Chitosan research in 2019
In 2019, many interesting and innovative research articles about chitosan and chitosan derivatives were published. In this article we present you an overview which chitosan reserach topics were important in 2019.
Chitosan – our passion!
The broad product portfolio of the Heppe Medical Chitosan GmbH reflects this passion. Clients and interested people can discover three fields of activity of the Heppe Medical Chitosan GmbH. Extensive knowledge can be shared e.g. in workshops. The production offers standard products and chitosan and chitosan derivatives according to customer specifications. In own laboratories analyses, research and developments are done in co-operation or by order.