The antiviral properties of chitosans, in contrast to chitosan derivatives, have been little considered. For this reason, the study presented here investigated the antiviral activity of three chitosans against the SARS-CoV-2 surrogate, bacteriophage phi6.

Hydrogels can have versatile applications in biomedicine by forming a 3D network. In the study presented here, an antibacterial, adhesive, self-repairing hydrogel was prepared from carboxymethylchitosan (CMC) and oligomeric polycyanidin (OPC) and the influence of OPC content was investigated.

Small interferring RNAs (siRNAs) can inactivate viruses by so-called gene silencing. In order to use this process in biomedicine, the transport of unstable siRNAs must be improved. In the presented study, siRNAs are coupled to chitosan microparticles and investigated for the inactivation of viral proteins in HIV-1 infected C8166 cells. siRNA transfection mediated by chitosan microparticles for the treatment of HIV-1 infections of human cell lines

Vaccines based on recombinant protein antigens often require immunostimulants. Both nanoparticles and chitosan and its derivatives can enhance immunogenicity. For this reason, in the presented studies, PLGA nanoparticles were functionalized with different chitosan derivatives and optimized as effect enhancers for the pneumococcal protein antigen PspA4Pro.

Critical bone defects often require the use of bone grafts or artificial bone substitutes such as calcium phosphate cement (CPC) or magnesium phosphate cement (MPC). In the study presented here, MPC is modified with CMC and sodium alginate to form a novel bone cement and its properties are investigated in vivo and in vitro.

Due to the increase of infectious diseases and the development of antibiotic resistance, new antibacterial substances are needed. In the presented study, novel chitosan-AgIO₃ bionanocomposites were synthesized and their antibacterial properties were investigated.