Publications in December 2010
In December 2010 116 articles dealing with chitosan or chitosan derivates were published. With 31 publications about chitosan China is the country which publicized the most ones followed by USA with 10 publications and India with 9. There chitosan nanoparticles, evaluation studies and pharmaceutical preparations were of most interest (37, 34 and 33 publications).
|J Biomed Mater Res A||6|
|Int J Biol Macromol||5|
|J Mater Sci Mater Med||4|
Table: Journals, which published motst articles about chitosan in December 2010
Three articles about application of chitosan are shortly introduced. The first reports about insulin delivery, the second is about cancer detection and the last about pollutant elimination.
Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery
Authors: Makhlof, Abdallah, Tozuka, Yuichi, Takeuchi, Hirofumi, Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010
The authors developed chitosan nanoparticles (CS NP) using the method of ionic cross-linking with hydroxypropyl methylcellulose phthalate (HPMCP) to create a pH-sensitive polymer for the oral delivery of insulin. It was shown that CS/HPMCP NPs exhibit a superior stability in acid and can control significantly the insulin release. Besides they were degraded in stimulated acidic conditions with or without pepsin. It was proved that the NPs are able to enhance the intestinal mucoadhesion and penetration. CS/HPMCP NPs could also increase the hypoglycemic effect of insulin.
PMID: 21182939 (www.gopubmed.de)
Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms
Authors: Yang, Shu-Jyuan, Lin, Feng-Huei, Tsai, Han-Min, Lin, Chia-Fu, Chin, Han-Chiang, Wong, Jau-Min, Shieh, Ming-Jium, Journal: Biomaterials, 2010
The authors developed a high-performance nanoparticle of a complex of alginate and folic acidmodified chitosan for photodynamic detection of colorectal cancer. These alginate-incorporated nanoparticles were loaded with 5-aminolevulinic acid (5-ALA) and readily taken up by colorectal cancer cells via folate receptor-mediated endocytosis. It was shown that the loading efficiency was 27 %. The reduction of the attraction intensity between chitosan and 5-ALA was initiated by deprotonation of the incorporated alginate in the lysosomes which results in the release of 5-ALA and thereby in a higher PplX accumulation for the photodynamic detection.
PMID: 21163518 (www.gopubmed.de)
Adsorption of As(III) on chitosan-Fe-crosslinked complex (Ch-Fe)
Authors: Dos Santos, Helen Helena, Demarchi, Carla Albertina, Rodrigues, Clovis Antonio, Greneche, Jean Marc, Nedelko, Nataliya, Slawska-Waniewska, Anna, Journal: Chemosphere, Vol. 82 (2): 278-83, 2011
The authors could demonstrate that a chitosan-Fe-crosslinked complex is able to adsorb As(III) on the surface. A non-linearized form Landmuir-Freundlich isotherm model offers the possibility to explain the theoretical correlation of the experimental equilibrium adsorbtion data for As (III)/Ch-Fe system. Santos et al. found a maximum for the adsorption capacity of 13.4 mgg-1 at optimum conditions, pH 9.0, like calculated. There the kinetics of the As(III) adsorption is represented by the pseudo-firstorder kinetic equation. The group also observed no redox process on the surface of the adsorbent.
PMID: 20943252 (www.pubmed.de)
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