head uk2

Publications in December 2010

In December 2010 116 articles dealing with chitosan or chitosan derivates were published. With 31 publications about chitosan China is the country which publicized the most ones followed by USA with 10 publications and India with 9. There chitosan nanoparticles, evaluation studies and pharmaceutical preparations were of most interest (37, 34 and 33 publications).

Journals Articles
J Biomed Mater Res A 6
Int J Biol Macromol 5
Biosens Bioelectron 5
J Mater Sci Mater Med 4
Biomaterials 3

Table: Journals, which published motst articles about chitosan in December 2010

Three articles about application of chitosan are shortly introduced. The first reports about insulin delivery, the second is about cancer detection and the last about pollutant elimination.


Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery

Authors: Makhlof, Abdallah, Tozuka, Yuichi, Takeuchi, Hirofumi, Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2010

The authors developed chitosan nanoparticles (CS NP) using the method of ionic cross-linking with hydroxypropyl methylcellulose phthalate (HPMCP) to create a pH-sensitive polymer for the oral delivery of insulin. It was shown that CS/HPMCP NPs exhibit a superior stability in acid and can control significantly the insulin release. Besides they were degraded in stimulated acidic conditions with or without pepsin. It was proved that the NPs are able to enhance the intestinal mucoadhesion and penetration. CS/HPMCP NPs could also increase the hypoglycemic effect of insulin.
PMID: 21182939 (

Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms

Authors: Yang, Shu-Jyuan, Lin, Feng-Huei, Tsai, Han-Min, Lin, Chia-Fu, Chin, Han-Chiang, Wong, Jau-Min, Shieh, Ming-Jium, Journal: Biomaterials, 2010

The authors developed a high-performance nanoparticle of a complex of alginate and folic acidmodified chitosan for photodynamic detection of colorectal cancer. These alginate-incorporated nanoparticles were loaded with 5-aminolevulinic acid (5-ALA) and readily taken up by colorectal cancer cells via folate receptor-mediated endocytosis. It was shown that the loading efficiency was 27 %. The reduction of the attraction intensity between chitosan and 5-ALA was initiated by deprotonation of the incorporated alginate in the lysosomes which results in the release of 5-ALA and thereby in a higher PplX accumulation for the photodynamic detection.
PMID: 21163518 (

Adsorption of As(III) on chitosan-Fe-crosslinked complex (Ch-Fe)

Authors: Dos Santos, Helen Helena, Demarchi, Carla Albertina, Rodrigues, Clovis Antonio, Greneche, Jean Marc, Nedelko, Nataliya, Slawska-Waniewska, Anna, Journal: Chemosphere, Vol. 82 (2): 278-83, 2011

The authors could demonstrate that a chitosan-Fe-crosslinked complex is able to adsorb As(III) on the surface. A non-linearized form Landmuir-Freundlich isotherm model offers the possibility to explain the theoretical correlation of the experimental equilibrium adsorbtion data for As (III)/Ch-Fe system. Santos et al. found a maximum for the adsorption capacity of 13.4 mgg-1 at optimum conditions, pH 9.0, like calculated. There the kinetics of the As(III) adsorption is represented by the pseudo-firstorder kinetic equation. The group also observed no redox process on the surface of the adsorbent.
PMID: 20943252 (


chitosan, nanoparticles, cancer, insulin, pollutant elimination

  • Created on .

Congress and fairs

Meet us in person 2023:

  • EASO Winterschool 2023, Wittenberg, Deutschland, 15.02.-18.02.2023
  • EUCHIS 2023, Siglufjörður, Island, 11.-14.09.2023
  • EPNOE 2023, Graz, Austria, 18.09.-22.09.2023
  • Asia Pacific Chitin and Chitosan Symposium 2023, Juju, Süd-Korea, 31.10.-03.11.2023
  • Bioeconomy Innovation Day, Brussels, Belgium, 16.11.2023

To arrange an appointment please contact Katja Richter via sales(at)


  • Heppe Medical Chitosan GmbH
    Heinrich-Damerow-Strasse 1
    06120 Halle (Saale)
  • Tel.: +49 (0) 345 27 996 300
    Fax: +49 (0) 345 27 996 378
  • This email address is being protected from spambots. You need JavaScript enabled to view it.
Contact | GTC / Terms of Use | Legal info | Copyright © 2023 Heppe Medical Chitosan GmbH | Privacy notice

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.