Orthopedic infections can be treated with antibiotic-loaded bone cements. However, due to the growing number of resistances, new formulations are needed to e.g. improve the drug release. For this reason, dual-antibiotic bone cement containing chitosan and chitosan oligosaccharide was prepared in the presented study.
The importance of antibiotics remains undiminished today. However, antibiotic resistance is increasing and few new agents are being discovered that can bypass them. In the following article, a chitosan-based nanomaterial was therefore developed that exploits the antimicrobial effect of chitosan to eliminate Salmonella typhimurium.