The global spread of SARS-CoV-2 can only be contained through vaccine development. Vector vaccines (DNA and viral) can be produced rapidly and inexpensively with current synthesis technologies. Challenges with DNA vaccines include degradation by DNases, inefficient uptake by antigen-presenting cells, and low immunogenicity. The Quil-A-loaded chitosan particulate adjuvant system (QAC) enables transport of plasmid DNA directly to target cells and delayed release over time. Here, we present two recent studies about chitosan-based delivery systems for vaccines.
Fungal infection with Candida of dentures is a common complication. The adhesion of microorganisms such as Candida is influenced by material properties such as surface charge, hydrophobicity and roughness. The formation of oral biofilms is associated with caries, periodontitis or denture stomatitis. It is therefore important to prevent the formation of biofilms, also because antifungal agents are of little help. The polymer polymethyl methacrylate (PMMA) is widely used for denture fabrication due to its biocompatibility, but it is susceptible to biofilm formation. Therefore, research into strategies to endow dentures with antifungal properties is important.
Adjuvants in vaccines are potent enhancers, which ensure that even small amounts of pathogens induce a permanent immune response. They are particularly necessary for inactivated vaccines and vaccines with antigen subunits. Several studies investigated chitosan as an adjuvant or antigen delivery system in various formulations (gels, aqueous dispersion, micro- and nanoparticles).
The development of a strong bond between implant surface and the surrounding bone substance, called osseointegration is important for successful integration of a dental implant. The coating of dental implants with chitosan is a promising approach to enable an accelerated and improved integration. In the following, we present two publications about chitosan-based coatings for dental implants.
14th PBP World Meeting/ Research Pharm, Vienna, Austria, 18.-21.03.2024
EPNOE Workshop on Analytics of Polysaccharides, ETH Zürich, Zürich, Switzerland, 25.-26.06.2024
CPHI, Milan, Italy, 08.-10.10.2024
MEDICA 2024, Düsseldorf, Germany, 11.-14.11.2024
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Contact
Heppe Medical Chitosan GmbH Heinrich-Damerow-Strasse 1 06120 Halle (Saale) Germany
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