Veröffentlichungen im Januar 2009 - Chitosananwendungen und Forschungsansätze in der Krebstherapie
Das Jahr ist frisch. Alle stehen wieder in den Startlöchern. Was wird das Forschungsthema des Jahres? Ist ein Trend schon im ersten Monat zu erkennen? Hier finden Sie es heraus - lesen Sie weiter...
23 Artikel nehmen Bezug auf klinische Fakten und Krankheiten mit folgenden Stichworten:
Wounds and Injuries; Neoplasms; Mucositis; Arthritis; Ethmoid Sinusitis [1], Nasal Obstruction [1], Candidiasis, Oral [1], Postoperative Hemorrhage [1
Wir haben Ihnen im folgenden die Veröffentlichungen zusammengestellt und uns in diesem Monat vor allem auf die Chitosananwendungen und Forschungsansätze in der Krebstherapie konzentriert.
Wounds and Injuries
- Falabella, C A, et al, Novel Macromolecular Crosslinking Hydrogel to Reduce Intra-Abdominal Adhesions., J Surg Res 2009 Jan; PMID: 19481223 [found with GoPubMed]
- Valentine, Rowan, et al, The efficacy of a novel chitosan gel on hemostasis after endoscopic sinus surgery in a sheep model of chronic rhinosinusitis. Am J Rhinol Allergy 2009 Jan-Feb;23(1):71-5, PMID: 19379616 [found with GoPubMed]
- Belov, A A, et al, [The textile materials containing chitosan and proteolytic complex from hepatopancreas of the crab, for the medical purposes], Biomed Khim 2009 Jan-Feb;55(1):61-7, PMID: 19351034 [found with GoPubMed]
- Garcia, Pablo, et al, Robotic laser tissue welding of sclera using chitosan films. Lasers Surg Med 2009 Jan;41(1):60-7, PMID: 19143017 [found with GoPubMed]
- Altman, Andrew M, et al, IFATS collection: Human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model. Stem Cells 2009 Jan;27(1):250-8, PMID: 18818439 [found with GoPubMed]
Mucositis
- Ranjha, Nazar M, Polymeric micelles of ammonium palmitoyl glycol chitosan and solubilization of camptothecin. PDA J Pharm Sci Technol 2009 Jan-Feb;63(1):81-7, PMID: 19455944 [found with GoPubMed]
- Valentine, Rowan, et al, The efficacy of a novel chitosan gel on hemostasis after endoscopic sinus surgery in a sheep model of chronic rhinosinusitis. Am J Rhinol Allergy 2009 Jan-Feb;23(1):71-53:
- Ishizuka, T, et al, Experimental evaluation of photocrosslinkable chitosan hydrogel as injection solution for endoscopic resection. Endoscopy 2009 Jan;41(1):25-8
Arthritis, Experimental
- Porporatto, C, et al, The biocompatible polysaccharide chitosan enhances the oral tolerance to type II collagen. Clin Exp Immunol 2009 Jan;155(1):79-87, PMID: 19076832 [found with GoPubMed]
- Howard, Kenneth A, et al, Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. 2: Mol Ther 2009 Jan;17(1):162-8
- PMID: 18827803 [found with GoPubMed]
Thinness
- Praig, Vera, et al, Localized surface plasmon resonance of gold nanoparticle-modified chitosan films for heavy-metal ions sensing., G Nanosci Nanotechnol 2009 Jan;9(1):350-7, PMID: 19441318 [found with GoPubMed]
- Kuse, Yasunori, et al, Molecular structure and liquid-crystalline characteristics of chitosan phenylcarbamate.Biomacromolecules 2009 Jan;10(1):166-73, PMID: 19067537 [found with GoPubMed]
Neoplasms
- Tiwari, Ashutosh,et al, Electrochemical detection of a breast cancer susceptible gene using cDNA immobilized chitosan-co-polyaniline electrode. Talanta 2009 Jan;77(3):1217-22,
Extract: An electrochemical breast cancer biosensor based on a chitosan-co-polyaniline (CHIT-co-PANI) copolymer coated onto indium-tin-oxide (ITO) was fabricated by immobilizing the complementary DNA (cDNA) probe (42 bases long) associated with the breast cancer susceptible gene BRCA1. ... For the cDNA/CHIT-co-PANI/ITO electrode, the amperometric current decreased linearly with an increasing logarithm of molar concentration of the single-stranded target DNA (ssDNA) within the range of 0.05-25fmol. The bioelectrode exhibited a sensitivity of 2.104 microA/fmol with a response time of 16s. The cDNA/CHIT-co-PANI/ITO electrode had a shelf life of about six months, even when stored at room temperature. PMID: 19064115 [found with GoPubMed]
- Yang, Shu-Jyuan, et al, Colorectal cancer cell detection by 5-aminolaevulinic acid-loaded chitosan nano-particles. Cancer Lett 2009 Jan;273(2):210-20
Extract: In this study, we designed an oral form nano-particle to encapsulate 5-aminolaevulinic acid (5-ALA) to improve the detection of colorectal cancer cells in vivo. The nano-particle should escape from bacteria uptake in the gastrointestinal tract which seriously interferes the results of endoscopic observation. In this study, chitosan was mixed with sodium tripolyphosphate (STPP) and 5-ALA to prepare chitosan nano-particles (CN) and 5-ALA loaded chitosan nano-particles (CNA) by adding different pH values and concentrations of 5-ALA solution. ... This result implies that CNA could exclude the influence of normal flora inside the gut and serves as an adequate tool for fluorescent endoscopic detection of colorectal cancer cells in vivo. PMID: 18809246 [found with GoPubMed]
- Kim, Dong-Hyun, et al, Targeting to carcinoma cells with chitosan- and starch-coated magnetic nanoparticles for magnetic hyperthermia. J Biomed Mater Res A 2009 Jan;88(1):1-11,
Extract: The delivery of hyperthermic thermoseeds to a specific target site with minimal side effects is an important challenge in targeted hyperthermia, which employs magnetic method and functional polymers. An external magnetic field is used to control the site-specific targeting of the magnetic nanoparticles. Polymer-coated magnetic nanoparticles can confer a higher affinity to the biological cell membranes. In this study, uncoated, chitosan-coated, and starch-coated magnetic nanoparticles were synthesized for use as a hyperthermic thermoseed. ... Hence, chitosan-coated magnetic nanoparticles are biocompatible and have a selective affinity to KB cells. The targeting of magnetic nanoparticles in hyperthermia was improved using a controlled magnetic field and a chitosan-coating. Therefore, chitosan-coated magnetic nanoparticles are expected to be promising materials for use in magnetic targeted hyperthermia. PMID: 18257079 [found with GoPubMed]
- Zhao, Z,, et al, Biodegradable Nanoparticles Based on Linoleic Acid and Poly(beta-malic acid) Double Grafted Chitosan Derivatives as Carriers of Anticancer Drugs. Biomacromolecules 2009 Jan;
Extract: Novel chitosan derivatives carrying linoleic acid (LA) as hydrophobic moieties and poly(beta-malic acid) (PMLA) as hydrophilic moieties (LA/PMLA double grafted chitosan, LMC) were synthesized. It self-assembled into nanoparticles of 190-350 nm in water, which carried negative surface charges in physiological pH. The critical aggregation concentration of the LMC deceased with an increase in the LA content. Paclitaxel (PTX) was loaded into the LMC nanoparticles with a high loading efficiency and the maximum loading capacity of 9.9 +/- 0.4%. ... Additionally, PTX-LMC showed significantly potent tumor inhibition efficacy relative to that of TAXOL in S-180 bearing mice. Therefore, the LMC nanoparticles could be an effective and safe vehicle for systemic administration of hydrophobic drugs, especially PTX. PMID: 19175304 [found with GoPubMed]
- Howard, Kenneth A, et al, Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol Ther 2009 Jan;17(1):162-8,
Extract: Secretion of tumor necrosis factor-alpha (TNF-alpha) by macrophages plays a predominant role in the development and progression of rheumatoid arthritis. We demonstrate that knockdown of TNF-alpha expression in systemic macrophages by intraperitoneal (i.p.) administration of chitosan/small interfering RNA (siRNA) nanoparticles in mice downregulates systemic and local inflammation. ... This work demonstrates nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages as a method to reduce both local and systemic inflammation, thereby presenting a novel strategy for arthritis treatment. PMID: 18827803 [found with GoPubMed]
- Bae, Ki Hyun, et al, Intracellular delivery of heparin complexed with chitosan-g-poly(ethylene glycol) for inducing apoptosis., Pharm Res 2009 Jan;26(1):93-100,
Extract: PURPOSE: Chitosan-g-PEG/heparin polyelectrolyte complex micelles were prepared for inducing apoptotic death of cancer cells. ... CONCLUSIONS: Nanosized and stable chitosan-g-PEG/heparin polyelectrolyte complex micelles were produced by a self-assembly process. The polyelectrolyte complex micelles facilitated the intracellular delivery of heparin, triggered the caspase activation, and consequently promoted apoptotic death of cancer cells.PMID: 18777202 [found with GoPubMed]
- Tan, Mei Lin, et al, Cancer, chitosan nanoparticles and catalytic nucleic acids. J Pharm Pharmacol 2009 Jan;61(1):3-12,
Extract: OBJECTIVES: The aim of this review was to examine gene therapy involving DNAzyme and siRNA encapsulation into chitosan nanoparticles, discussing the current and future status of this drug delivery system in enhancing drug delivery and cancer therapy. ... As a result drug delivery systems have been developed in attempts to deliver therapeutics specifically to the target lesion site. One recent drug delivery system has revolved around the use of chitosan nanoparticle technology, where therapeutics are encapsulated into nanoparticles and targeted to tumours. SUMMARY: Though few, attempts at encapsulating therapeutics such as deoxyribozymes and small or short interfering RNA have been optimistic and encouraging. PMID: 19126291 [found with GoPubMed]
Enteritis [2]
1: Zhu, Longzhang; et al. Chitosan-coated magnetic nanoparticles as carriers of 5-fluorouracil: preparation, characterization and cytotoxicity studies. Colloids Surf B Biointerfaces 2009 Jan68(1):1-6; PMID: 19013060 [found with GoPubMed]
2: Kaur, Karanjit et al. Studies of chitosan/organic acid/Eudragit RS/RL-coated system for colonic delivery. Int J Pharm 2009 Jan366(1-2):140-8; PMID: 18835342 [found with GoPubMed]
Ethmoid Sinusitis [1], Nasal Obstruction [1], Candidiasis, Oral [1], Postoperative Hemorrhage [1
